Histopathological evaluation of inflammatory skin diseases with clinical correlation: A hospital based cross sectional study

Abstract

Skin diseases are diverse however, most of the conditions are diagnosed based on visual examination and clinical history^1. Skin being the largest organ of the human body presents with diversity of diseases. Majority of the skin diseases can be diagnosed by history,clinical presentation and biochemical investigation without need of histopathology². Clinical manifestations may vary with disease duration and may be ameliorated with treatment.⁵ This situation provides us finding out diagnosis, stages of lesions, pathogenesis and even etiological factors of dermatological diseases. There are many techniques such as histopathology, immunopathology, and electron microscopy for diagnosis of disease after biopsy. Evaluating of all clinical and histopathological findings is important, Diagnosis of skin diseases is not based on just clinical findings but also on histopathological findings.

Aim:

To evaluate age, gender, clinical preliminary diagnoses of patients biopsied and to correlate these with histopathological diagnoses.

Materials and methods:

Study conducted for a period of two years on 107 skin biopsies received at department of pathology in a tertiary care centre. Detailed clinical history was taken and the biopsies were subjected to H&E with special stains and IHC support wherever required.

Results:

107patients were included in this study.55 patients were males (52%) and 52 patients (48%) were females. Among inflammatory skin lesions, lichen planus constituted 21 cases of lesions, followed by 22 cases of psoriasis, 8 cases of dermatitis ,7 cases of lupus lesions.