MICROBIAL ECOLOGY OF CHILDHOOD ASTHMA: DECIPHERING THE INTERPLAY AMONG MICROBIOTA, ALLERGENS, AND HOST DEFENSE

Abstract

The burden of Paediatric asthma, a chronic respiratory illness with an alarming increase in its 
occurrence, affects millions of children. The development and exacerbation of asthma are closely 
associated with the dysbiosis of the airway microbiota, environmental allergens, and host 
immunity. The interplay between microbiota, environmental allergens, host immunity and 
dysbiosis of the airway microbiota is a critical area of research in the pathogenesis and progression 
of childhood asthma. Novel therapeutic interventions such as microbiome-based therapies or 
personalized immunomodulatory treatments ought to be developed. We investigate the 
possibilities of such therapeutic interventions, targeting the microbiota's dysbiosis and the immune 
system's dysregulation, which will certainly lead to more effective treatment and management of 
childhood asthma. The present review article attempts to explore the interplay between microbiota, 
environmental allergens, and host immunity in the development of childhood asthma, while 
highlighting the importance of probiotics, prebiotics, and immunomodulatory drugs in 
modulating the microbiome which improves asthma outcomes. The article also elaborates on the 
recent findings and potential future directions of innovative research and therapeutic interventions