In vivo Antiulcer activity of Elephantopusscaber Linn.

Abstract

Peptic ulcer is a public health problem with a high rate of morbidity and significant mortality and has become the subject of experimental and clinical investigations, mostly due to its great prevalence in the global population. The present research has been designed to explore the E. scaberfor its antiulcer activity. The plant material was successively extracted by the Soxhlet extraction technique with Petroleum ether, chloroform, methanol, and water. The antioxidant activity of the plant extracts and the standard drugs were based on consideration of the radical scavenging influence of the stable "1,1-diphenyl-2-picrylhydrazyl" (DPPH) free radical action and hydrogen peroxide process. Two models, and non-steroidal anti-inflammatory induced ulcer and pyloric ligation, were analysed for methanolic extract of E. scaberfor its antiulcer activity. The phytochemical examination of methanolic extracts reveals the presence of triterpenoids, flavonoids, alkaloids, tannins, glycosides, and proteins. The antioxidant study results revealed that among all the four extracts, the MEESpossesses significant antioxidant potential. Compared with control, there were a significant (p<0.05) decrease in gastric volume, total and free acidity in the extract-treated classesand standard class. The MEES revealed significant (p<0.05) percent inhibition, i.e. 59.42 and 69.59 percent with 500 mg mL-1 PL and NSAID, respectively. The present research findings demonstrated that the methanolic extract of E. Scaber possesses significant antioxidant and antiulcer activity.