MUCOADHESIVE MICROSPHERES- A PROMISING CARRIER IN DRUG DELIVERY OF ROSIGLITAZONE MALEATE FORMULATION

Abstract

The aim of present study is development of mucoadhesive microspheres of Rosiglitazone maleate by combine the potential advantages of mucoadhesion with controlled drug delivery using various ratio of polymers.To achieve optimum therapeutic drug level over extended period of time, a controlled release system in the form of mucoadhesive microspheres will be developed using widely accepted and physiologically safe excipient and using simple techniques and reproducible methodologiesMucoadhesive microspheres of Rosiglitazone maleate are designed to increase its residence time in stomach by interacting with mucus membrane. Mucoadhesive microspheres of Rosiglitazone maleate will be prepared by using various ratios of carbopol-934, sodium carboxy methyl cellulose and sodium alginate by emulsification solvent evaporation techniques.