FORMULATION, EVALUATION AND DEVELOPMENT OF CELLULOSE DERIVATIVES GEL CONTAINING ANTI-FUNGAL DRUG LOADED NANOSPONGES

Abstract

The main objective of this study is to create and assess the properties of Gel containing BH Nanosponges that may function as efficient antifungal drug delivery systems (DDS) for the therapeutic treatment of fungal infections by delaying the medication release. Using a natural linear polymer and the solvent emulsion evaporation process, nano sponge was created (Cellulose and Polymethyl methacrylate). Butenafine Hydrochloride Nanosponges (F4) had a mean average particle size of 377.4 nm and a Z average of 341 nm. Zeta potential was found to be -27.7 and the polydispersity index was determined to be 0.152. The formulations of the Nanosponges were evaluated for their percentages of production yield (PY), entrapment efficiency (EE), and drug loading (%DL) (DL). The F4 formulation had the highest values at 70%w/w, 79.48% w/w, and 19.48% w/w, respectively. The drug release of the marketed formulation was found to be 100.5 in 150 minutes, while the in-vitro drug release of pure drug, drug containing nano sponges improved formulation (F4), and gel containing optimized nano sponges was found to be 33.35, 57.75, and 76.13, respectively. The butenafine hydrochloride loaded nano sponges Gel may have increased water solubility, percentage drug release, volume of drug loading, antifungal activity (significantly increased in Zone of Inhibition), and offer sustained impact after all results were seen.