A CHILD WITH GROWTH HORMONE INSENSITIVITY- LARON SYNDROME - CASE REPOR

Abstract

Laron syndrome(LS) is one of the rare genetic causes of short stature that occurs due to growth 
hormone resistance. It is caused by mutations in growth hormone receptor gene causing growth 
retardation, craniofacial defects, high serum Growth hormone and low insulin-like growth factorI (IGF-I) levels. In this article we report a 18 month old girl child, brought to the hospital with an 
alleged history of trivial injury by falling from bed about 1 to 2 feet high. There were no signs of 
head injury. Physical examination revealed short stature and underweight. Her length was 65cm, 
less than -3SD and weight was 5.8Kg, less than -3SD. Basal serum GH level was elevated (22.83 
ng/mL), whereas serum IGF-I levels are significantly low. Clinical and laboratory parameters were 
matching with that of Laron syndrome. This condition is managed by Recombinant IGF-I therapy.