Biomimetics As a Natural Alternative for Tooth Remineralization a Systematic Review

Abstract

Dental enamel, primarily composed of hydroxyapatite nanocrystals, is susceptible to 
demineralization despite its formidable strength. Biomimetic remineralization, inspired by natural 
processes, offers promising non-invasive therapeutic avenues for restoring enamel. This review 
explores various biomimetic agents, including grape seed extract, Galla chinensis, propolis, Aloe 
vera, ginger & honey, theobromine, hesperidin, gum arabic, and tea polyphenols, highlighting their 
mechanisms and efficacy in promoting remineralization. Studies underscore the potential of these 
agents in enhancing enamel strength, inhibiting caries pathogens, and promoting remineralization. 
Despite challenges in clinical application and variations in research findings, biomimetic 
remineralization holds significant promise for revolutionizing preventive and restorative dentistry. 
The purpose of this paper is to provide a systematic review of knowledge about natural alternatives 
for tooth remineralization